Denham Springs is the largest area of commercial and residential development in Livingston Parish, and is the only parish municipality classed as a city. Its population is approximately 10,200.

The city is situated in the area of the east-west highways US 190 and Interstate 12, and the major north-south artery in western Livingston Parish, LA Hwy 16. Denham Springs is also located on the Illinois Central Gulf Railroad, an east-west line which played a large role in the city’s early development. The Amite River forms a portion of the municipality’s boundary, but the river at this point is not navigable except by small boats.